Research Funded

Abstract: Osteosarcoma (OS) is the most common bone sarcoma, and is treated with surgery, chemotherapy, and radiation therapy. 30-40% of patients treated with curative intent relapse. In patients that recur, survival is less than 20... Read More

Abstract: Currently, most sarcoma reference centers prefer a conventionally fractionated preoperative radiotherapy (RT) schedule (25 x 2 Gy in 5 weeks) over postoperative RT to 66 Gy for extremity soft tissue sarcoma patients. This ... Read More

Abstract: Ewing sarcoma (EwS) is the second most common bone and soft tissue tumor of children and young adults. Despite being one of the most aggressive pediatric cancers, outcomes for EwS patients have not changed in decades, with... Read More

Abstract: Ewing Sarcoma (ES) is the second most common and an aggressive bone cancer which occurs in children and young adults. While upfront therapy is effective for many patients with newly diagnosed localized ES, the prognosis re... Read More

Abstract: Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue cancers and one of the most common types of soft tissue cancers in children and adolescent/young adults. MPNST is most often associated with Neuro... Read More

Abstract: Dedifferentiated liposarcomas (DDLPS) is the most frequent high-grade soft tissue sarcoma in adults, and characterized by a significant risk of metastatic relapse and death. New active systemic therapies are urgently neede... Read More

Abstract: Desmoplastic small round cell tumors (DSRCTs) are rare, often incurable abdominal sarcomas that present in pediatric and young adolescent populations. It arises from a translocation resulting in a fusion protein (FP), the ... Read More

Abstract: Chondrosarcomas (CS), the most common form of bone cancer, can be extremely aggressive with high mortality rates. Therapeutic options for CS have not advanced in the last few decades, where resistance to chemo- and radiati... Read More

Abstract: Soft tissue sarcomas are aggressive cancers originating from connective tissues, often found in the limbs, chest wall, or abdomen. Despite successful surgery for localized tumors, over half of sarcoma patients face the ris... Read More

Abstract: Leiomyosarcoma (LMS) is a cancer defined by smooth muscle differentiation and is one of the most common sarcomas. Outcomes for LMS patients have not improved in decades: 50% of LMS patients develop metastases, for which th... Read More

Abstract: Osteosarcoma, an aggressive bone cancer primarily affecting children, adolescents, and young adults, poses a significant global health challenge with an annual incidence of 26,000 new cases. Despite incremental advancement... Read More

Abstract: Background and Significance: Leiomyosarcoma (LMS) is one of the most common sarcoma types and is characterized by high metastatic rates and mortality. LMS arises from smooth muscle cells of various tissues and organs. Desp... Read More

Abstract: SPECIFIC AIMS. Immunotherapy is a promising treatment approach, but at least two immunologic phenomena—antigen escape and T cell exhaustion—are emerging as key biologic obstacles to effective immunotherapy for most sol... Read More

Abstract: The MDM2 oncogene is frequently amplified or overexpressed in sarcoma, particularly liposarcoma. Despite the development of selective MDM2 inhibitors, there are currently no effective clinical strategies to target tumors w... Read More

Abstract: Cancer immunotherapies have revolutionized how some tumor types are treated. However, evidence for their benefit in sarcoma patients remains limited with only small subsets of patients responding to treatments. Impressive ... Read More

Abstract: Substantial progress has been made in the treatment of paediatric patients affected by oncological malignancies over the past decades. However, children with high-risk, metastatic or relapsed disease continue to have poor ... Read More

Abstract: Leiomyosarcoma (LMS) is one of the most common soft tissue sarcomas, representing up to 20% of all of them. Many LMS originate directly from smooth muscle cells or from their precursor showing a predilection for uterus, la... Read More

Abstract: Kaposi sarcoma (KS) is a highly vascularized tumor of the skin and viscera that is driven by the oncogenic Kaposi Sarcoma Herpesvirus (KSHV). Skin KS can cause painful edema while visceral KS of the lungs or gastrointestin... Read More

Abstract: Approximately 20% of sarcomas are driven by oncogenic translocations, which commonly involve transcriptional regulators. Alveolar soft part sarcoma (ASPS) is a sarcoma most commonly diagnosed in young adults and characteri... Read More

Abstract: CIC-DUX4 sarcoma (CDS) is a highly aggressive and metastatic cancer that mainly affects children and young adults, and the prognosis for the affected is very poor with an overall survival of only 14 months. Currently, with... Read More

Abstract: Rhabdomyosarcoma (RMS), the most common STS in pediatric, adolescent and young adult patients. RMS is a devastating malignancy; outcomes for patients with high-risk disease are dismal and unlike many pediatric cancers, hav... Read More

Abstract: Over the past decade, immunotherapy has revolutionized cancer care across many cancer types by harnessing the body’s immune system to fight tumor cells. However, response to current immunotherapies in undifferentiated pl... Read More

Abstract: The body’s immune system has a tremendous ability to fight disease including cancer, with strategies to reinvigorate immune responses against cancer winning the Nobel Prize in 2018 – and multiple immunotherapy drugs ap... Read More

Abstract: Desmoplastic small round cell tumor (DSRCT) is a rare, usually incurable, pediatric sarcoma that afflicts mostly young males. While the EWS-WT1 fusion protein (FP) is a hallmark of DSRCT, equally pervasive is the dense fib... Read More