Funded Research

Functional Genomic Characterization of a Conditional Mouse Model of Alveolar Rhabdomyosarcoma: Comparison to Human Tumors

Alveolar Rhabdomyosarcoma

“Molecular Dissection of a Subset of Gene Fusion-Associated Sarcomas that Lack the Gene Fusion”

Osteosarcoma

A mouse model to examine human osteosarcoma therapeutic options

Ewing Sarcoma

Lipid-Sensing ETV6 Vulnerability in Ewing Sarcoma

Developing multipronged cell therapy for RMS

Undifferentiated Pleomorphic Sarcoma

Targeting ATRX mutation in UPS

Angiosarcoma

Understanding and targeting MYC in angiosarcoma

An Implantable Microdevice in Soft Tissue Sarcoma

CIC-rearranged Sarcoma

WEE1/PKMYT1 Dual Targeting in CIC::DUX4 Sarcoma

Osteosarcoma| Ewing Sarcoma| Synovial Sarcoma

Translation of Autophagy-Reprogrammed B7-H3 CAR T

Epithelioid Sarcoma

Optimizing CDK4/6 blockade in epithelioid sarcoma

Ewing Sarcoma

EWS::FLI1 drives tumorigenesis in part by creating aberrant, phase-separated, nuclear speckle-related biomolecular condensates that dysregulate mRNA splicing

Undifferentiated Pleomorphic Sarcoma

Siglec15 Regulation of Immune Suppressive Microenvironment in Sarcoma

Osteosarcoma

Next Generation CAR NK Combinatorial Immunotherapy against Osteosarcoma

Leiomyosarcoma| Undifferentiated Pleomorphic Sarcoma

Identification of YAP-Dependent High-Grade Complex Karyotype Sarcomas

Myxoid Liposarcoma

Investigating Intratumoral Heterogeneity and Outcomes in Myxoid/Round Cell Liposarcoma

CIC-rearranged Sarcoma

Pediatric and Young Adult Undifferentiated Round Cell Sarcomas beyond Ewing Sarcoma: Establishing in vitro Models and Discovery of Novel Therapeutic Targets of CIC::DUX4 Sarcoma

Desmoplastic Small Round Cell Tumor

Investigating lineage plasticity and EMT through the ZEB1-GRHL2 axis in DSRCT

Spindle Cell / Sclerosing Rhabdomyosarcoma| Alveolar Rhabdomyosarcoma| Embryonal Rhabdomyosarcoma

Uncovering mechanisms of adoptive cellular therapy dysfunction in rhabdomyosarcoma

Dedifferentiated Liposarcoma| Leiomyosarcoma| Atypical Lipomatous Tumor

Translational study of the phase III randomized EORTC-62092 STRASS trial (TRANS-STRASS)

Leiomyosarcoma

Pre-Clinical Development of Synergistic Drug Combinations Studies Targeting DNA Damage Response Inhibitors in Leiomyosarcoma

Spindle Cell / Sclerosing Rhabdomyosarcoma| Pleomorphic Rhabdomyosarcoma| Alveolar Rhabdomyosarcoma| Embryonal Rhabdomyosarcoma

Reduced Human Leukocyte Antigen Expression in Rhabdomyosarcoma: Implications for Immune Recognition

Pleomorphic Rhabdomyosarcoma

Defining and targeting the mechanisms of post-operative immune suppression in soft tissue sarcoma

Gastrointestinal Stromal Tumor

Regulation of KIT gene expression in gastrointestinal stromal tumor

Leiomyosarcoma

Leiomyosarcoma Cell Line Compound Screening

Epithelioid Haemangioendothelioma

Evaluation of a Cdk9 inhibitor for the treatment of aggressive epithelioid hemangioendothelioma

Clear Cell Sarcoma of Soft Tissue| Synovial Sarcoma| Alveolar Soft Part Sarcoma

September 9, 2024

Generating T cell Immunity to Sarcoma by Liposomal Vaccination with Sarcoma Fusion Breakpoints

Osteosarcoma

September 9, 2024

Identification of Tumor Suppressor (LOH18CR) on Chromosome 18

Angiosarcoma

Outbred Canine Model of Adjuvant Immunotherapy for Angiosarcoma

Ewing Sarcoma

Development of novel dual Insulin-like Growth Factor-1 Receptor (IGF-1R)/ Epidermal Growth Factor Receptor (EGFR) inhibitors for treatment of Ewing’s sarcoma

Leiomyosarcoma

Exploring novel immunotherapy combination strategies and identifying predictive biomarkers for patients with Uterine Leiomyosarcoma.

Ewing Sarcoma

Oncogenic Targets of Hedgehog-GL/1 Activation in Ewing Sarcoma

Ewing Sarcoma

Targeting GLI1 in Ewing Sarcoma

Ewing Sarcoma

Developing an effective targeted therapy for undifferentiated round cell sarcomas by directly targeting CIC-DUX4 fusion and Myc oncoproteins

Synovial Sarcoma

Blocking SYT-SSX activities using an inhibitory peptide

Extraskeletal Myxoid Chondrosarcoma

Identification of the target genes of the EWS/NR4A3 fusion protein expressed in extraskeletal myxoid Chondrosarcoma

Angiosarcoma

Unraveling the tumor immune microenvironment of angiosarcomas

Osteosarcoma

miR-15b (miRNA-15b) delivery to reverse multidrug resistance in human osteosarcoma

Osteosarcoma

Functional analysis of Mirk/Dyrk 1B in osteosarcoma

All

Targeting kinases to reverse multidrug resistance in human sarcoma

Osteosarcoma

Identification of Tumor Suppressor (LOH18CR) on Chromosome 18

Synovial Sarcoma

Elimination of Macrophages to Improve T cell Therapy in Synovial Sarcoma

Myxoid Liposarcoma| Synovial Sarcoma

The Next Generation of Antigen-Specific T cells for Sarcoma Therapies for Sarcoma

Myxoid Liposarcoma| Synovial Sarcoma

Unmasking Immunomodulatory Effects of Radiation in Synovial and Myxoid/ Round Cell Liposarcoma

Alveolar Rhabdomyosarcoma| Embryonal Rhabdomyosarcoma

THE ROLE OF PSEUDOGENES AS REGULATORS OF THE IGF2BP2/IGF1R/RAS AXIS IN RHABDOMYOSARCOMA: FUNCTIONAL CHARACTERIZATION IN MYOGENESIS AND IMPLICATIONS FOR ANTICANCER THERAPY

Alveolar Rhabdomyosarcoma

Identifying native and heteroclitic epitopes for T-cell immunity to PAX3-FKHR alveolar rhabdomyosarcoma

Alveolar Soft Part Sarcoma

Immunologic Monitoring of Patients with Alveolar Soft Part Sarcoma Receiving a Long Translocation-Specific Peptide Vaccine with GM-CSF Adjuvant

Synovial Sarcoma

Oncolytic virotherapy: An alternative immune based strategy leveraging cancer testis antigens in synovial sarcoma

Gastrointestinal Stromal Tumor

Pre-clinical development of anti-KIT CAR-Ts for metastatic GIST

Ewing Sarcoma

Evaluation of flow cytometry for the detection of circulating Ewing sarcoma cells

Osteosarcoma

Inspecting the Stroma to Eliminate Metastatic Osteosarcoma

Ewing Sarcoma

Targeting Ewing Sarcoma using a novel CAR T cell therapy

Ewing Sarcoma

Endoglin CAR T cells for Immunotherapy of Ewing Sarcoma

Osteosarcoma

Analysis of Cancer Health Disparities in Osteosarcoma by scRNA-seq

Undifferentiated Pleomorphic Sarcoma

Towards precision immunotherapy for Undifferentiated Pleomorphic Sarcoma

Modulating cell state as sarcoma therapy

Osteosarcoma

Early identification of chemoresistant patients for improved risk-based therapy in pediatric osteosarcoma

Clinical Evaluation of BET and HDAC Inhibition in Canine Sarcoma

Atypical Lipomatous Tumor| Dedifferentiated Liposarcoma

Genomewide therapeutic target screens in novel preclinical models of liposarcoma

Conventional Chordoma| Poorly Differentiated Chordoma| Dedifferentiated Chordoma

Targeting FGFR/MEK/ERK/Brachyury pathway to inhibit chordoma cell growth

Ewing Sarcoma| Osteosarcoma| Alveolar Rhabdomyosarcoma| Embryonal Rhabdomyosarcoma| Spindle Cell / Sclerosing Rhabdomyosarcoma

Dissecting the contribution of germline genetics to pediatric sarcoma pathogenesis

“SCOPES”, towards a reduced treatment burden for soft tissue sarcoma patients

Clear Cell Sarcoma of Soft Tissue| Alveolar Soft Part Sarcoma

A small molecule that targets MiT/TFE dysregulated sarcomas

Alveolar Rhabdomyosarcoma

BMI1 as a Novel Driver and Target in Alveolar Rhabdomyosarcoma

Ewing Sarcoma| Synovial Sarcoma

Targeting Sarcoma Cancer Stem Cells with Natural Killer Cell Immunotherapy

Leiomyosarcoma

Exploiting the therapeutic efficacy of eribulin in leiomyosarcoma through a better knowledge of its complex mechanism of action

Immunotargeting of the prognostic NG2/CSPG4 cell surface proteoglycan in soft-tissue histotypes

Undifferentiated Pleomorphic Sarcoma| Leiomyosarcoma

Translational studies in the GEMMK trial: Optimising immunotherapy in leiomyosarcoma and undifferentiated pleomorphic sarcoma

Ewing Sarcoma

In vivo activity and characterization of the mechanism of action of a novel class of proteasome inhibitors in Ewing’s sarcoma

CIC-rearranged Sarcoma

Overcoming fusion oncoprotein dependence through CIC-DUX4 target gene inhibition in undifferentiated sarcoma

Atypical Lipomatous Tumor| Myxoid Liposarcoma| Myxoid Pleomorphic Liposarcoma| Dedifferentiated Liposarcoma| Pleomorphic Liposarcoma

Ribonucleotide reductase as a novel target in liposarcoma

Osteosarcoma

Identifying mechanisms of osteosarcoma chemoresistance that arise from the lung metastatic niche

All

Tumor Angiogenesis in Different Organ Environments: Implications for Anti-VEGF Therapy for Soft Tissue Sarcomas

All

Analysis of targeted biological therapies in a genetically engineered mouse model of sarcoma

Dedifferentiated Liposarcoma

Tumor-specific PROTACs that exploit amplified MDM2 in dedifferentiated liposarcoma

Leiomyosarcoma

A preclinical mouse model for targeted therapy in uterine leiomyosarcoma

Extrarenal Rhabdoid Tumor

Differentiation Therapy for Rhabdoid Tumors

Dedifferentiated Liposarcoma

CD24: a new therapeutic target in dedifferentiated liposarcoma

Ewing Sarcoma

Identification of aberrantly methylated genes in Ewing sarcoma

Myxoid Liposarcoma| Synovial Sarcoma

Modulation of Cold Sarcoma Microenvironments to Enable T Cells in Experimental Systems

Atypical Lipomatous Tumor| Myxoid Liposarcoma| Myxoid Pleomorphic Liposarcoma| Dedifferentiated Liposarcoma| Pleomorphic Liposarcoma

Lipid Metabolism in Liposarcoma: A Novel Target for Therapeutic Intervention

Leiomyosarcoma

Comprehensive Genomic Analysis of Metatstatic Uterine and Extrauterine Leiomyoscarcoma

Osteosarcoma

Therapeutically Targeting the Hippo Pathway in Osteosarcoma

Alveolar Rhabdomyosarcoma| Embryonal Rhabdomyosarcoma| Spindle Cell / Sclerosing Rhabdomyosarcoma

Exploiting Tertiary Lymphoid Structures in Rhabdomyosarcoma for promoting immunotherapy response.

Osteosarcoma

Identification and Characterization of Tumor-Initiating Cells in Human Osteocarcoma – A Model to Unravel the “Roots of Evil” in Bone Cancer

Atypical Lipomatous Tumor| Myxoid Liposarcoma| Myxoid Pleomorphic Liposarcoma| Dedifferentiated Liposarcoma| Pleomorphic Liposarcoma

Epigenetic changes and epigenetic therapy in retroperitoneal liposarcomas

Angiosarcoma

Characterising the Proteomic Landscape of Angiosarcomas

Tenosynovial Giant Cell Tumor

CSF1 inhibitors in soft tissue tumors

Osteosarcoma

Epigenomic characterization of paired primary and metastatic osteosarcoma tumors to define novel therapeutic targets.

Osteosarcoma

Enabling anti-tumor immunity in osteosarcoma through manipulation of the pRb pathway

Atypical Lipomatous Tumor| Dedifferentiated Liposarcoma

Study of miR-26a-2 gene as a therapeutic target of human liposarcoma

Gastrointestinal Stromal Tumor

Targeting ETV1 in Gastrointestinal Stromal Tumor (GIST)

Ewing Sarcoma

Functional validation and targeting of ENPP1 in Ewing sarcoma

Ewing Sarcoma

Examining oncofusion-driven transcript and protein isoforms that underpin fitness relationships essential for Ewing sarcoma tumor formation and metastasis

Infantile Fibrosarcoma

Interrogating the effects of IGF1R blockade on childhood sarcoma fusion oncoprotein stability

Osteosarcoma

Modulation of the tumor immune microenvironment by targeting STAT3 and CD47-SIRPa axis for the treatment of osteosarcoma-lung metastasis.

Atypical Lipomatous Tumor| Undifferentiated Pleomorphic Sarcoma| Osteosarcoma| Dedifferentiated Liposarcoma| Leiomyosarcoma

Structural and functional genomics characterization of complex karyotype sarcomas for targeting perturbed telomere maintenance mechanisms

Epithelioid Sarcoma

Histone deacetylase inhibitor reprograms hSNF5/INI1 regulated gene expression for the treatment of epithelioid sarcoma

Osteosarcoma

Nanoparticle-based Targeting Tumor Neoangiogenesis to Improve Surgical Resection of PrimaryTtumor and Lung Metastasis in Advanced Osteosarcoma

Malignant Peripheral Nerve Sheath Tumour

Targeting the Notch Signaling Pathway: A Novel Method to Inhibit Sarcomas with Constitutive Ras Activation

Clear Cell Sarcoma of Soft Tissue| Synovial Sarcoma| Alveolar Soft Part Sarcoma

Generating T cell Immunity to Sarcoma by Liposomal Vaccination with Sarcoma Fusion Breakpoints

All

Hedgehog palmitoylation inhibitors to block sarcoma growth

Gastrointestinal Stromal Tumor

Comprehensive mutational analysis of gastrointestinal stromal tumors lacking activating mutations in the KIT, PDGFRA, and BRAF genes

Ewing Sarcoma

Immunomodulation of Ewing sarcoma to enhance allogenic NK cell therapy

All

Molecular Classification of Sarcoma Cell Lines

Leiomyosarcoma

Liquid biopsy in patients with uterine leiomyosarcoma

Alveolar Soft Part Sarcoma

Characterizing and targeting the oncogenic program in Alveolar Soft Part Sarcoma

Gastrointestinal Stromal Tumor| Leiomyosarcoma

Exploring sarcoma functional genomics to identify disease-specific vulnerabilities.

CART Cells for Sarcoma

Leiomyosarcoma

A Phase II Study of the PARP Inhibitor Olaparib in Combination with the DNA Damaging Agent Temozolomide for the Treatment of Advanced Uterine Leiomyosarcoma

Leiomyosarcoma

Developing a MicroRNA-Based Strategy for Targeting Uterine Leiomyosarcoma

Leiomyosarcoma

Targeting centrosomes in uterine leiomyosarcoma

Ewing Sarcoma

Adoptive cellular therapy for Ewing’s sarcoma

Kinase Activity Profiling in Soft Tissue Sarcoma

Osteosarcoma

Targeting the Hedgehog pathway to inhibit osteosarcoma growth through dual effects on tumor and microenvironment cells

Secondary peripheral chondrosarcoma, grades 2 and 3| Secondary Peripheral Atypical Cartilaginous Tumor / Chondrosarcoma, Grade 1

Mitochondrial Epigenetic Processes and Transfers in Chondrosarcoma Cancers with Mutant IDH2

Ewing Sarcoma

Targeting Actin-like 6A (ACTL6A) for Ewing Sarcoma (EwS) Treatment

Ewing Sarcoma

Identification of causative mutations for Ewing sarcoma

Desmoid Fibromatosis

A Phase III, double blind, randomized, placebo-controlled trial of sorafenib in desmoid tumors or aggressive fibromatosis (DT/DF)

Angiosarcoma| Osteosarcoma

Combination therapy with a novel humanized antibody to secreted frizzled related protein 2 for sarcoma

Gastrointestinal Stromal Tumor| Leiomyosarcoma

Targeting the RB-pathway in sarcoma: Utility of CDK4/6 inhibitors

Osteosarcoma

Using In Vivo Fluorescence Angiography to Evaluate the Impact of Small Molecule Anti-Metastatic Inhibitors of Osteosarcoma in an Immunocompetent Mouse Model

Osteosarcoma

Investigation Of Novel Anti-Metastatic Therapies For Osteosarcoma

Malignant Peripheral Nerve Sheath Tumour

Single-cell transcriptomics and epigenomics to identify tumor-microenvironment Interactions for targeted treatment of MPNST

Atypical Lipomatous Tumor| Dedifferentiated Liposarcoma

Combining Th1 specific multi-antigen cancer vaccines and radiation for liposarcoma treatment

Synovial Sarcoma

Function and targeting of a 5hmC-methylosome complex in synovial sarcoma

Desmoplastic Small Round Cell Tumor

Desmoplastic Small Round Cell Tumor: Establishment and Validation of New Cell Lines and Therapeutic Targeting of the EWS-WT1 Transcription Factor using Splice Switching Oligonucleotides

Malignant Peripheral Nerve Sheath Tumour

The immunomodulatory effects of RAS signaling pathway inhibitors in MPNST

Angiosarcoma

A Novel Genetically Engineered Mouse Model for Angiosarcoma: Molecular Characterization and Comparison to Human Angiosarcoma to Develop Targeted Therapy

Osteosarcoma

The Role of RECQ Helicases in the Pathogenesis of Osteosarcoma

Mesenchymal Chondrosarcoma

The PDGF/PI3K/AKT Axis in Mesenchymal Chondrosarcoma: Functional Characterization and Implications for Anticancer Therapy

Angiosarcoma

Identification of Causative Genetic Networks in Angiosarcoma

Desmoplastic Small Round Cell Tumor

Identification of novel drug targets and predictors of clinical outcomes in desmoplastic small round cell tumors using next-generation sequencing

Synovial Sarcoma

Development of a Mouse Model of Synovial Sarcoma

Synovial Sarcoma

Identifying the sources of synovial sarcoma

Ewing Sarcoma

Modeling, Characterizing, and Targeting Aggressive, STAG2-mutated Ewing Sarcoma

Ewing Sarcoma

Multi-faceted immunostimulatory therapy for Ewing Sarcoma (MITES)

Ewing Sarcoma

Epigenetic Mechanisms underlying Ewing Sarcoma Pathogenesis

Ewing Sarcoma

Global impact of the DNA/RNA helicase DHX9 on the processing of coding and noncoding transcripts in Ewing sarcoma pathogenesis

Clear Cell Sarcoma of Soft Tissue| Synovial Sarcoma| Undifferentiated Pleomorphic Sarcoma| Angiosarcoma| Alveolar Soft Part Sarcoma

Phase I-II trial of sunitinib plus nivolumab after standard treatment in advanced soft tissue and bone sarcomas

Myxoid Liposarcoma

Obstruction of Transcription at Tumorigenic Chromosomal Translocations as Therapy

Osteosarcoma| Alveolar Rhabdomyosarcoma| Embryonal Rhabdomyosarcoma| Spindle Cell / Sclerosing Rhabdomyosarcoma

Redirecting B7H3 CAR T cells To Sarcoma using Midkine Receptors

Undifferentiated Pleomorphic Sarcoma

Switching the tumor immune microenvironment from “cold” to “hot” in UPS

Embryonal Rhabdomyosarcoma

Evaluation of the Hedgehog Signaling Pathway in the Growth of Myogenic Sarcomas

All

Sarcoma Cell Line Resource with Molecular and Kinase Annotation

Angiosarcoma

ROS1 kinase as a candidate molecular target in angiosarcoma

Reversing Exhaustion of Anti-Sarcoma T cells

Osteosarcoma

Analysis and Implications of the Difference in Response Rates to a Treatment For Metastatic Osteosarcoma

Leiomyosarcoma

Genomic and Spatial Landscapes of Leiomyosarcoma with Germline Pathogenic Variants

Atypical Lipomatous Tumor| Dedifferentiated Liposarcoma

Intratumoral heterogeneity in dedifferentiated liposarcoma

Synovial Sarcoma

Targeting the Wnt pathway in synovial sarcoma

Central Atypical Cartilaginous Tumor / Chondrosarcoma, Grade 1| Central Chondrosarcoma, Grades 2 and 3| Dedifferentiated Chondrosarcoma

Deciphering the effects of IDH mutations on chromatin and differentiation in chondrosarcoma

All

Proteomic Analysis of Sarcoma: Molecular Differences between Benign and Malignant Tumors of Bone and Soft Tissue

Osteosarcoma

Dual targeting of CDK4/6 and PI3K/mTOR in high-risk osteosarcoma

All

Cancer stem cells and sarcoma

Osteosarcoma

The Cancer Genome as a Novel Target for Malignant Osteosarcoma Immunotherapy

Synovial Sarcoma

Beta-catenin activation in synovial sarcomagenesis and progression

Secondary peripheral chondrosarcoma, grades 2 and 3| Secondary Peripheral Atypical Cartilaginous Tumor / Chondrosarcoma, Grade 1

Polarity and Ploidy in Peripheral Chondrosarcoma

Alveolar Rhabdomyosarcoma

How does a sarcoma circumvent fusion oncoprotein-mediated toxicity?

All

Predicting treatment response of soft tissue sarcomas to neoadjuvant therapy by imaging proliferation with a FLT-PET/CT scan: a pilot study

Synovial Sarcoma

Pluripotent Stem Cell-derived Genome-edited Sarcoma-targeted T cells for Immunotherapy

Dedifferentiated Liposarcoma

The sarcoma tumor microbiome as a therapeutic target

Leiomyosarcoma

Identifying DNA damage repair-related vulnerabilities in leiomyosarcoma

Undifferentiated Pleomorphic Sarcoma

Understand and target ATRX mutation in undifferentiated sarcoma

Atypical Lipomatous Tumor| Myxoid Liposarcoma| Myxoid Pleomorphic Liposarcoma| Dedifferentiated Liposarcoma| Pleomorphic Liposarcoma

A novel precision medicine approach to treat advanced liposarcoma

Dedifferentiated Liposarcoma

Desmoplastic small round cell tumor: validation and further development of novel active compounds emerging from high-throughput chemical screens and establishment of xenografts for preclinical studies

Myxoid Liposarcoma

Imaging response to CD47 mAb immunotherapy in pediatric patients with osteosarcoma

Pleomorphic Liposarcoma

Improve functionality and persistence of Chimeric Antigen Receptor redirected T cells in refractory/relapsed sarcoma patients by Beclin1 modulation

Myxoid Pleomorphic Liposarcoma

Regulation of sarcomagenesis by the Piwi proteins and their interacting small RNAs (piRNAs)

Gastrointestinal Stromal Tumor

Identification of therapeutic strategies to restore cell cycle control in GIST

Angiosarcoma

Predicting the response of secondary angiosarcomas to cemiplimab

Ewing Sarcoma

EWS-FLI1 triggered opportunistic de novo enhancer assembly activates potential cellular therapy targets in Ewing Sarcoma

Osteosarcoma

Comprehensive analysis of osteosarcoma genomes and transcriptomes using long-read sequencing technologies

Ewing Sarcoma

Uncovering polygenic signatures of Ewings Sarcoma drug sensitivity during the evolution of resistance

Synovial Sarcoma

Modeling Epithelioid Sarcomagenesis in the Mouse

Synovial Sarcoma

Examination of the molecular and therapeutic effects of mTOR and PDGFRA inhibition in Advanced Synovial Sarcoma.

Gastrointestinal Stromal Tumor

Chromatin accessibility regulates tyrosine kinase inhibitor resistance in Gastrointestinal Stromal Tumors

Ewing Sarcoma

C-MYC Target Gene Network in the Ewing’s Sarcoma Cancer Stem Cell

Conventional Chordoma| Dedifferentiated Chordoma| Poorly Differentiated Chordoma

Preclinical Testing of Compounds Identified in a High Throughput Screen as Potential Chordoma Therapies

Embryonal Rhabdomyosarcoma

Targeting the Ras-pathway for the treatment of embryonal rhabdomyosarcoma

All

Using Molecular Imaging to Identify Microscopic Residual Sarcoma Cells During Surgery

Alveolar Rhabdomyosarcoma| Embryonal Rhabdomyosarcoma| Spindle Cell / Sclerosing Rhabdomyosarcoma

Developing an accurate genetic model for rhabdomyosarcoma therapy testing

Osteosarcoma

“Targeting the Inactivation of the MYC Oncogene to Treat Osteogenic Sarcoma”

Osteosarcoma

Crosstalk between EGFR and IGF1R mediated by polymorphisms in the EGFR promoter as a mechanism for resistance to IGF1R directed therapy in osteosarcoma

CAR T Cell Therapy for Sarcoma

Osteosarcoma

A small molecule inhibitor of AXL is a novel therapeutic strategy in osteosarcoma

Embryonal Rhabdomyosarcoma

Identify and characterize therapeutic targets against cancer stemness and chemotherapy resistance in rhabdomyosarcoma

Alveolar Rhabdomyosarcoma| Embryonal Rhabdomyosarcoma

Next Generation CRISPR Phenotypic Screens for Identification of Novel Therapeutic Targets in Rhabdomyosarcoma

Embryonal Rhabdomyosarcoma

Targeting YAP/HIPPO pathway in embryonal rhabdomyosarcoma

Undifferentiated Pleomorphic Sarcoma

Prognostic and Predictive Immune Signatures in Undifferentiated Pleomorphic Sarcomas

Atypical Lipomatous Tumor| Undifferentiated Pleomorphic Sarcoma| Dedifferentiated Liposarcoma

Evaluating the Chromatin Accessibility Landscape as a Driver of Clinical Behavior in Primary Treatment Naive Liposarcoma

Ewing Sarcoma

Translational assessment of predictive factors of response of Ewing sarcoma to genotoxic therapy

Ewing Sarcoma

Characterization of the function of a novel lncRNA in Ewing’s sarcoma using genomics and proteomics

Angiosarcoma

Targeting the sarcoma tumor microenvironment using adrenergic receptor antagonists

Leiomyosarcoma

Study of the mechanisms of sarcoma progression using mouse models and in vitro manipulation of mesenchymal stem cells

Malignant Peripheral Nerve Sheath Tumour

RalA as a novel target for treatment of MPNST

Osteosarcoma

Using 3D bioprinting technologies to Create an Organ-on-Chip Device for Osteosarcoma and Its Surrounding Bone Microenvironment: A Platform for Drug Discovery and Therapeutic Innovation

Synovial Sarcoma| Ewing Sarcoma| Osteosarcoma

BiCAR-VZV T cells for the treatment of Sarcoma

Alveolar Rhabdomyosarcoma

Role of SFRP3 in PAX3-FOXO1-positive alveolar rhabdomyosarcoma

Malignant Peripheral Nerve Sheath Tumour

Mechanisms of tumor progression and kinome targeting in peripheral nerve sheath tumors

All

Pharmacodynamic assessment of AKT and SRC inhibitors in primary human sarcoma xenograft models

Desmoplastic Small Round Cell Tumor

Identifying EWS::WT1 Control and The Utility of Neogenes in Desmoplastic Small Round Cell Tumors

Desmoplastic Small Round Cell Tumor

Omic characterization of DSRCT and establishing the role of fibroblasts

Osteosarcoma

Carbon-ion radiotherapy for enhancing treatment response to osteosarcoma

Infantile Fibrosarcoma| Adult Fibrosarcoma| Myxofibrosarcoma| Low-Grade Fibromyxoid Sarcoma| Sclerosing Epithelioid Fibrosarcoma

Sarcoma Immunotherapy by Attenuated Salmonella Typhimurium Engineered for Tumor Specific Production of Immunomodulators.

Adult Fibrosarcoma

Enhanced NK cell Immunotherapy for Treatment of Chemotherapy Refractory Sarcoma

Myxofibrosarcoma

Hypoxia-Associated Multiomic Changes in Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma

Low-Grade Fibromyxoid Sarcoma

Development of T cell receptors targeting the common cancer antigen PRAME in pediatric malignancies

Sclerosing Epithelioid Fibrosarcoma

Characterizing the Genetic Landscape of Radiation Associated Cutaneous Angiosarcomas

Osteosarcoma

Identification of molecular targets promoting differentiation and loss of self renewal in osteosarcoma

Undifferentiated Pleomorphic Sarcoma

Dissecting Mechanisms of Immune Mediated Radiation Resistance in Sarcomas

Osteosarcoma

Identifying chemoresistance pathways in Osteosarcoma.

All

Predicting Chemotherapy Response in Sarcoma using Molecular and Imaging Data Collected in a Digital Registry

Ewing Sarcoma

Identification of novel therapeutic targets in Ewing’s Sarcoma by modeling tumorigenesis in differentiating human embryonic stem cells.

Alveolar Rhabdomyosarcoma

A role for injury in sarcomagenesis

Osteosarcoma

An in vivo study of molecular genetics of Rb-dependent osteosarcoma

Ewing Sarcoma

Evaluation of ctDNA as a prognostic biomarker in patients with localized Ewing sarcoma

Alveolar Rhabdomyosarcoma| Embryonal Rhabdomyosarcoma| Spindle Cell / Sclerosing Rhabdomyosarcoma

Understanding the determinants of cell fate decisions in pediatric rhabdomyosarcomas

Angiosarcoma

Targeting Angiosarcoma Vascular and Metabolic Signaling by Blocking Beta Adrenergic Receptor Signaling

Leiomyosarcoma

Resetting the epigenetic addiction in leiomyosarcomas: a therapeutic perspective

Osteosarcoma

The Role of MYC Amplification in Shaping the Osteosarcoma Tumor Microenvironment

All

Boosting Tumor Immunogenicity to Enhance Response to Immune Checkpoint Inhibitors in Soft Tissue Sarcomas

All

Discovery of small molecule inhibitors of the MDM2-ubcH5 interaction

All

Mechanisms of Arginine Starvation Induced Cell Death

All

Determining Doxorubicin Effects on Plasma Extracellular Vesicles Using Proteomics Analysis

All

Targeting the alterations of Lipid Metabolism in ASS1 Deficient Sarcomas to Induce Synthetic Lethality

Synovial Sarcoma

Targeting the Pentose Phosphate Pathway for the Treatment of Synovial Sarcoma

Synovial Sarcoma| Ewing Sarcoma| Osteosarcoma| Leiomyosarcoma

A METABOLOMIC APPROACH TO TARGETING ASS1 DEFICIENT SARCOMAS

Alveolar Rhabdomyosarcoma

Plexin-Semaphorin: a new signaling axis in Sarcomas

All

Therapeutically targeting aberrant chromatin remodeling in sarcomas

Osteosarcoma

Interrogating the regulation, function and therapeutic potential of monocarboxylate transporters in osteosarcoma

Alveolar Rhabdomyosarcoma

Unwinding new therapeutic opportunities in rhabdomyosarcoma: the role of RNA helicase DDX5

All

Delineating Strategies to Enhance Immunotherapy Response via Microbial Targeting of Tertiary Lymphoid Structures

Inflammatory Myofibroblastic Tumour

Identifying and characterizing actionable kinase fusions in Inflammatory Myofibroblastic Tumors

Osteosarcoma

Improving T-cell Therapy for Osteosarcoma

Osteosarcoma

B7-H3-Engager T cells for the immunotherapy of osteosarcoma

Leiomyosarcoma

Omic patterns of sensitivity and resistance to existing agents

Ewing Sarcoma

Development of Novel RNA Sensor-Based Treatment for Ewing’s Sarcoma

Osteosarcoma| Embryonal Rhabdomyosarcoma

Uncover principles underlying cryoablation-induced immunotherapy effects in sarcomas

Extrarenal Rhabdoid Tumor

Epigenetic control of stem cell identity in rhabdoid sarcomas

Dedifferentiated Liposarcoma

Evaluation of the oncogenic potential of genes within the 1q23 amplicon

Undifferentiated Pleomorphic Sarcoma

Improving CAR-T cell immunotherapy in immunocompetent sarcoma models

Synovial Sarcoma| Undifferentiated Pleomorphic Sarcoma

A Quantitative Imaging-based Biomarker for Assessment of Therapy Response in Soft Tissue Sarcomas by Differential Volume Estimation of Viable and Non-viable Tumor Fractions

Rational biomarker-guided PARP inhibitor combination therapy in pediatric sarcomas

PEComa (Perivascular Epithelioid Tumour)

Integrative multi-Omic analysis of PEComa: biomarkers and novel therapeutic targets

Pleomorphic Rhabdomyosarcoma

Immune profiling of pleomorphic rhabdomyosarcoma

Atypical Lipomatous Tumor| Dedifferentiated Liposarcoma

Proteomic and genomic approaches to understanding intrinsic and acquired resistance to CDK4 inhibition therapy in well differentiated/dedifferentiated liposarcoma

Dedifferentiated Liposarcoma

Dissecting DNA damage and repair pathways in leiomyosarcomas: Improving therapy by understanding biology

Central Atypical Cartilaginous Tumor / Chondrosarcoma, Grade 1| Central Chondrosarcoma, Grades 2 and 3| Dedifferentiated Chondrosarcoma

Targeting the retinoid acid pathway: a new therapeutic strategy for IDH1/2-mutant chondrosarcomas

Kaposi Sarcoma

Towards an improved Kaposi sarcoma immunotherapy: Investigating the interplay of the oncogenic Kaposi sarcoma herpesvirus G-protein coupled receptor with the host chemokine system

Leiomyosarcoma

Hippo pathway targeting in uterine leiomyosarcoma

Synovial Sarcoma

MCL-1 inhibition unmasks BCL-2 addiction in synovial sarcoma

Ewing Sarcoma

Targeting EWS-FLI1 Ewing Sarcoma through a rationale targeted therapy combination

Undifferentiated Pleomorphic Sarcoma

Evaluating myeloid cells as targets to promote anti-tumor immunity in undifferentiated pleomorphic sarcoma

Ewing Sarcoma