Funded Research

September 1, 2024

Functional Genomic Characterization of a Conditional Mouse Model of Alveolar Rhabdomyosarcoma: Comparison to Human Tumors

Alveolar Rhabdomyosarcoma

September 1, 2024

“Molecular Dissection of a Subset of Gene Fusion-Associated Sarcomas that Lack the Gene Fusion”

Osteosarcoma

September 1, 2024

A mouse model to examine human osteosarcoma therapeutic options

Ewing Sarcoma

August 19, 2025

EWS::FLI1 drives tumorigenesis in part by creating aberrant, phase-separated, nuclear speckle-related biomolecular condensates that dysregulate mRNA splicing

Undifferentiated Pleomorphic Sarcoma

August 19, 2025

Siglec15 Regulation of Immune Suppressive Microenvironment in Sarcoma

Osteosarcoma

August 19, 2025

Next Generation CAR NK Combinatorial Immunotherapy against Osteosarcoma

August 19, 2025

Identification of YAP-Dependent High-Grade Complex Karyotype Sarcomas

Myxoid Liposarcoma

August 19, 2025

Investigating Intratumoral Heterogeneity and Outcomes in Myxoid/Round Cell Liposarcoma

Ewing Sarcoma| CIC-rearranged Sarcoma

August 19, 2025

Pediatric and Young Adult Undifferentiated Round Cell Sarcomas beyond Ewing Sarcoma: Establishing in vitro Models and Discovery of Novel Therapeutic Targets of CIC::DUX4 Sarcoma

Desmoplastic Small Round Cell Tumor

August 19, 2025

Investigating lineage plasticity and EMT through the ZEB1-GRHL2 axis in DSRCT

Spindle Cell / Sclerosing Rhabdomyosarcoma| Pleomorphic Rhabdomyosarcoma| Alveolar Rhabdomyosarcoma| Embryonal Rhabdomyosarcoma

August 19, 2025

Uncovering mechanisms of adoptive cellular therapy dysfunction in rhabdomyosarcoma

Dedifferentiated Liposarcoma| Leiomyosarcoma

August 19, 2025

Translational study of the phase III randomized EORTC-62092 STRASS trial (TRANS-STRASS)

Leiomyosarcoma

August 19, 2025

Pre-Clinical Development of Synergistic Drug Combinations Studies Targeting DNA Damage Response Inhibitors in Leiomyosarcoma

Spindle Cell / Sclerosing Rhabdomyosarcoma| Pleomorphic Rhabdomyosarcoma| Alveolar Rhabdomyosarcoma| Embryonal Rhabdomyosarcoma

August 19, 2025

Reduced Human Leukocyte Antigen Expression in Rhabdomyosarcoma: Implications for Immune Recognition

August 19, 2025

Defining and targeting the mechanisms of post-operative immune suppression in soft tissue sarcoma

Gastrointestinal Stromal Tumor

August 19, 2025

Regulation of KIT gene expression in gastrointestinal stromal tumor

Leiomyosarcoma

August 19, 2025

Leiomyosarcoma Cell Line Compound Screening

Epithelioid Haemangioendothelioma

August 19, 2025

Evaluation of a Cdk9 inhibitor for the treatment of aggressive epithelioid hemangioendothelioma

Clear Cell Sarcoma of Soft Tissue| Synovial Sarcoma| Alveolar Soft Part Sarcoma

September 9, 2024

Generating T cell Immunity to Sarcoma by Liposomal Vaccination with Sarcoma Fusion Breakpoints

Osteosarcoma

September 9, 2024

Identification of Tumor Suppressor (LOH18CR) on Chromosome 18

Angiosarcoma

September 1, 2024

Outbred Canine Model of Adjuvant Immunotherapy for Angiosarcoma

Ewing Sarcoma

September 1, 2024

Development of novel dual Insulin-like Growth Factor-1 Receptor (IGF-1R)/ Epidermal Growth Factor Receptor (EGFR) inhibitors for treatment of Ewing’s sarcoma

Leiomyosarcoma

September 1, 2024

Exploring novel immunotherapy combination strategies and identifying predictive biomarkers for patients with Uterine Leiomyosarcoma.

Ewing Sarcoma

September 1, 2024

Oncogenic Targets of Hedgehog-GL/1 Activation in Ewing Sarcoma

Ewing Sarcoma

September 1, 2024

Targeting GLI1 in Ewing Sarcoma

Ewing Sarcoma

September 1, 2024

Developing an effective targeted therapy for undifferentiated round cell sarcomas by directly targeting CIC-DUX4 fusion and Myc oncoproteins

Synovial Sarcoma

September 1, 2024

Blocking SYT-SSX activities using an inhibitory peptide

Extraskeletal Myxoid Chondrosarcoma

September 1, 2024

Identification of the target genes of the EWS/NR4A3 fusion protein expressed in extraskeletal myxoid Chondrosarcoma

Angiosarcoma

September 1, 2024

Unraveling the tumor immune microenvironment of angiosarcomas

Osteosarcoma

September 1, 2024

miR-15b (miRNA-15b) delivery to reverse multidrug resistance in human osteosarcoma

Osteosarcoma

September 1, 2024

Functional analysis of Mirk/Dyrk 1B in osteosarcoma

All

September 1, 2024

Targeting kinases to reverse multidrug resistance in human sarcoma

Osteosarcoma

September 1, 2024

Identification of Tumor Suppressor (LOH18CR) on Chromosome 18

Synovial Sarcoma

September 1, 2024

Elimination of Macrophages to Improve T cell Therapy in Synovial Sarcoma

Myxoid Liposarcoma| Synovial Sarcoma

September 1, 2024

The Next Generation of Antigen-Specific T cells for Sarcoma Therapies for Sarcoma

Myxoid Liposarcoma| Synovial Sarcoma

September 1, 2024

Unmasking Immunomodulatory Effects of Radiation in Synovial and Myxoid/ Round Cell Liposarcoma

Spindle Cell / Sclerosing Rhabdomyosarcoma

September 1, 2024

THE ROLE OF PSEUDOGENES AS REGULATORS OF THE IGF2BP2/IGF1R/RAS AXIS IN RHABDOMYOSARCOMA: FUNCTIONAL CHARACTERIZATION IN MYOGENESIS AND IMPLICATIONS FOR ANTICANCER THERAPY

Spindle Cell / Sclerosing Rhabdomyosarcoma

September 1, 2024

Identifying native and heteroclitic epitopes for T-cell immunity to PAX3-FKHR alveolar rhabdomyosarcoma

Alveolar Soft Part Sarcoma

September 1, 2024

Immunologic Monitoring of Patients with Alveolar Soft Part Sarcoma Receiving a Long Translocation-Specific Peptide Vaccine with GM-CSF Adjuvant

Synovial Sarcoma

September 1, 2024

Oncolytic virotherapy: An alternative immune based strategy leveraging cancer testis antigens in synovial sarcoma

Gastrointestinal Stromal Tumor

September 1, 2024

Pre-clinical development of anti-KIT CAR-Ts for metastatic GIST

Ewing Sarcoma

September 1, 2024

Evaluation of flow cytometry for the detection of circulating Ewing sarcoma cells

Osteosarcoma

September 1, 2024

Inspecting the Stroma to Eliminate Metastatic Osteosarcoma

Ewing Sarcoma

September 1, 2024

Targeting Ewing Sarcoma using a novel CAR T cell therapy

Ewing Sarcoma

September 1, 2024

Endoglin CAR T cells for Immunotherapy of Ewing Sarcoma

Osteosarcoma

September 1, 2024

Analysis of Cancer Health Disparities in Osteosarcoma by scRNA-seq

Undifferentiated Pleomorphic Sarcoma

September 1, 2024

Towards precision immunotherapy for Undifferentiated Pleomorphic Sarcoma

September 1, 2024

Modulating cell state as sarcoma therapy

Osteosarcoma

September 1, 2024

Early identification of chemoresistant patients for improved risk-based therapy in pediatric osteosarcoma

Infantile Fibrosarcoma| Adult Fibrosarcoma| Myxofibrosarcoma| Low-Grade Fibromyxoid Sarcoma| Sclerosing Epithelioid Fibrosarcoma| Undifferentiated Pleomorphic Sarcoma

September 1, 2024

Clinical Evaluation of BET and HDAC Inhibition in Canine Sarcoma

Atypical Lipomatous Tumor| Dedifferentiated Liposarcoma

September 1, 2024

Genomewide therapeutic target screens in novel preclinical models of liposarcoma

September 1, 2024

Targeting FGFR/MEK/ERK/Brachyury pathway to inhibit chordoma cell growth

| Ewing Sarcoma| Osteosarcoma

September 1, 2024

Dissecting the contribution of germline genetics to pediatric sarcoma pathogenesis

September 1, 2024

“SCOPES”, towards a reduced treatment burden for soft tissue sarcoma patients

Clear Cell Sarcoma of Soft Tissue| Alveolar Soft Part Sarcoma

September 1, 2024

A small molecule that targets MiT/TFE dysregulated sarcomas

September 1, 2024

BMI1 as a Novel Driver and Target in Alveolar Rhabdomyosarcoma

September 1, 2024

Targeting Sarcoma Cancer Stem Cells with Natural Killer Cell Immunotherapy

Leiomyosarcoma

September 1, 2024

Exploiting the therapeutic efficacy of eribulin in leiomyosarcoma through a better knowledge of its complex mechanism of action

Atypical Lipomatous Tumor| Infantile Fibrosarcoma| Adult Fibrosarcoma| Myxofibrosarcoma| Low-Grade Fibromyxoid Sarcoma| Sclerosing Epithelioid Fibrosarcoma| Undifferentiated Pleomorphic Sarcoma| Dedifferentiated Liposarcoma| Leiomyosarcoma

September 1, 2024

Immunotargeting of the prognostic NG2/CSPG4 cell surface proteoglycan in soft-tissue histotypes

Undifferentiated Pleomorphic Sarcoma| Leiomyosarcoma

September 1, 2024

Translational studies in the GEMMK trial: Optimising immunotherapy in leiomyosarcoma and undifferentiated pleomorphic sarcoma

Ewing Sarcoma

September 1, 2024

In vivo activity and characterization of the mechanism of action of a novel class of proteasome inhibitors in Ewing’s sarcoma

CIC-rearranged Sarcoma

September 1, 2024

Overcoming fusion oncoprotein dependence through CIC-DUX4 target gene inhibition in undifferentiated sarcoma

Atypical Lipomatous Tumor| Myxoid Liposarcoma| Myxoid Pleomorphic Liposarcoma| Dedifferentiated Liposarcoma| Pleomorphic Liposarcoma

September 1, 2024

Ribonucleotide reductase as a novel target in liposarcoma

Osteosarcoma

September 1, 2024

Identifying mechanisms of osteosarcoma chemoresistance that arise from the lung metastatic niche

All

September 1, 2024

Tumor Angiogenesis in Different Organ Environments: Implications for Anti-VEGF Therapy for Soft Tissue Sarcomas

All

September 1, 2024

Analysis of targeted biological therapies in a genetically engineered mouse model of sarcoma

Dedifferentiated Liposarcoma

September 1, 2024

Tumor-specific PROTACs that exploit amplified MDM2 in dedifferentiated liposarcoma

Leiomyosarcoma

September 1, 2024

A preclinical mouse model for targeted therapy in uterine leiomyosarcoma

Extrarenal Rhabdoid Tumor

September 1, 2024

Differentiation Therapy for Rhabdoid Tumors

Dedifferentiated Liposarcoma

September 1, 2024

CD24: a new therapeutic target in dedifferentiated liposarcoma

Ewing Sarcoma

September 1, 2024

Identification of aberrantly methylated genes in Ewing sarcoma

Myxoid Liposarcoma| Synovial Sarcoma

September 1, 2024

Modulation of Cold Sarcoma Microenvironments to Enable T Cells in Experimental Systems

Atypical Lipomatous Tumor| Myxoid Liposarcoma| Myxoid Pleomorphic Liposarcoma| Dedifferentiated Liposarcoma| Pleomorphic Liposarcoma

September 1, 2024

Lipid Metabolism in Liposarcoma: A Novel Target for Therapeutic Intervention

Leiomyosarcoma

September 1, 2024

Comprehensive Genomic Analysis of Metatstatic Uterine and Extrauterine Leiomyoscarcoma

Osteosarcoma

September 1, 2024

Therapeutically Targeting the Hippo Pathway in Osteosarcoma

September 1, 2024

Exploiting Tertiary Lymphoid Structures in Rhabdomyosarcoma for promoting immunotherapy response.

Osteosarcoma

September 1, 2024

Identification and Characterization of Tumor-Initiating Cells in Human Osteocarcoma – A Model to Unravel the “Roots of Evil” in Bone Cancer

Atypical Lipomatous Tumor| Myxoid Liposarcoma| Myxoid Pleomorphic Liposarcoma| Dedifferentiated Liposarcoma| Pleomorphic Liposarcoma

September 1, 2024

Epigenetic changes and epigenetic therapy in retroperitoneal liposarcomas

Angiosarcoma

September 1, 2024

Characterising the Proteomic Landscape of Angiosarcomas

Tenosynovial Giant Cell Tumor

September 1, 2024

CSF1 inhibitors in soft tissue tumors

Osteosarcoma

September 1, 2024

Epigenomic characterization of paired primary and metastatic osteosarcoma tumors to define novel therapeutic targets.

Osteosarcoma

September 1, 2024

Enabling anti-tumor immunity in osteosarcoma through manipulation of the pRb pathway

Atypical Lipomatous Tumor| Dedifferentiated Liposarcoma

September 1, 2024

Study of miR-26a-2 gene as a therapeutic target of human liposarcoma

Gastrointestinal Stromal Tumor

September 1, 2024

Targeting ETV1 in Gastrointestinal Stromal Tumor (GIST)

Ewing Sarcoma

September 1, 2024

Functional validation and targeting of ENPP1 in Ewing sarcoma

Ewing Sarcoma

September 1, 2024

Examining oncofusion-driven transcript and protein isoforms that underpin fitness relationships essential for Ewing sarcoma tumor formation and metastasis

Infantile Fibrosarcoma

September 1, 2024

Interrogating the effects of IGF1R blockade on childhood sarcoma fusion oncoprotein stability

Osteosarcoma

September 1, 2024

Modulation of the tumor immune microenvironment by targeting STAT3 and CD47-SIRPa axis for the treatment of osteosarcoma-lung metastasis.

Atypical Lipomatous Tumor| Undifferentiated Pleomorphic Sarcoma| Osteosarcoma| Dedifferentiated Liposarcoma| Leiomyosarcoma

September 1, 2024

Structural and functional genomics characterization of complex karyotype sarcomas for targeting perturbed telomere maintenance mechanisms

Epithelioid Sarcoma

September 1, 2024

Histone deacetylase inhibitor reprograms hSNF5/INI1 regulated gene expression for the treatment of epithelioid sarcoma

Osteosarcoma

September 1, 2024

Nanoparticle-based Targeting Tumor Neoangiogenesis to Improve Surgical Resection of PrimaryTtumor and Lung Metastasis in Advanced Osteosarcoma

Malignant Peripheral Nerve Sheath Tumour

September 1, 2024

Targeting the Notch Signaling Pathway: A Novel Method to Inhibit Sarcomas with Constitutive Ras Activation

Clear Cell Sarcoma of Soft Tissue| Synovial Sarcoma| Alveolar Soft Part Sarcoma

September 1, 2024

Generating T cell Immunity to Sarcoma by Liposomal Vaccination with Sarcoma Fusion Breakpoints

All

September 1, 2024

Hedgehog palmitoylation inhibitors to block sarcoma growth

Gastrointestinal Stromal Tumor

September 1, 2024

Comprehensive mutational analysis of gastrointestinal stromal tumors lacking activating mutations in the KIT, PDGFRA, and BRAF genes

Ewing Sarcoma

September 1, 2024

Immunomodulation of Ewing sarcoma to enhance allogenic NK cell therapy

All

September 1, 2024

Molecular Classification of Sarcoma Cell Lines

Leiomyosarcoma

September 1, 2024

Liquid biopsy in patients with uterine leiomyosarcoma

Alveolar Soft Part Sarcoma

September 1, 2024

Characterizing and targeting the oncogenic program in Alveolar Soft Part Sarcoma

Gastrointestinal Stromal Tumor| Leiomyosarcoma

September 1, 2024

Exploring sarcoma functional genomics to identify disease-specific vulnerabilities.

| | Synovial Sarcoma| Ewing Sarcoma| Osteosarcoma

September 1, 2024

CART Cells for Sarcoma

Leiomyosarcoma

September 1, 2024

A Phase II Study of the PARP Inhibitor Olaparib in Combination with the DNA Damaging Agent Temozolomide for the Treatment of Advanced Uterine Leiomyosarcoma

Leiomyosarcoma

September 1, 2024

Developing a MicroRNA-Based Strategy for Targeting Uterine Leiomyosarcoma

Leiomyosarcoma

September 1, 2024

Targeting centrosomes in uterine leiomyosarcoma

Ewing Sarcoma

September 1, 2024

Adoptive cellular therapy for Ewing’s sarcoma

| Infantile Fibrosarcoma| Adult Fibrosarcoma| Low-Grade Fibromyxoid Sarcoma| Sclerosing Epithelioid Fibrosarcoma| Atypical Lipomatous Tumor| Dedifferentiated Liposarcoma| Synovial Sarcoma| Leiomyosarcoma

September 1, 2024

Kinase Activity Profiling in Soft Tissue Sarcoma

Osteosarcoma

September 1, 2024

Targeting the Hedgehog pathway to inhibit osteosarcoma growth through dual effects on tumor and microenvironment cells

Secondary peripheral chondrosarcoma, grades 2 and 3| Secondary Peripheral Atypical Cartilaginous Tumor / Chondrosarcoma, Grade 1

September 1, 2024

Mitochondrial Epigenetic Processes and Transfers in Chondrosarcoma Cancers with Mutant IDH2

Ewing Sarcoma

September 1, 2024

Targeting Actin-like 6A (ACTL6A) for Ewing Sarcoma (EwS) Treatment

Ewing Sarcoma

September 1, 2024

Identification of causative mutations for Ewing sarcoma

Desmoid Fibromatosis

September 1, 2024

A Phase III, double blind, randomized, placebo-controlled trial of sorafenib in desmoid tumors or aggressive fibromatosis (DT/DF)

Angiosarcoma| Osteosarcoma

September 1, 2024

Combination therapy with a novel humanized antibody to secreted frizzled related protein 2 for sarcoma

Gastrointestinal Stromal Tumor| Leiomyosarcoma

September 1, 2024

Targeting the RB-pathway in sarcoma: Utility of CDK4/6 inhibitors

Osteosarcoma

September 1, 2024

Using In Vivo Fluorescence Angiography to Evaluate the Impact of Small Molecule Anti-Metastatic Inhibitors of Osteosarcoma in an Immunocompetent Mouse Model

Osteosarcoma

September 1, 2024

Investigation Of Novel Anti-Metastatic Therapies For Osteosarcoma

Malignant Peripheral Nerve Sheath Tumour

September 1, 2024

Single-cell transcriptomics and epigenomics to identify tumor-microenvironment Interactions for targeted treatment of MPNST

Atypical Lipomatous Tumor| Dedifferentiated Liposarcoma

September 1, 2024

Combining Th1 specific multi-antigen cancer vaccines and radiation for liposarcoma treatment

Synovial Sarcoma

September 1, 2024

Function and targeting of a 5hmC-methylosome complex in synovial sarcoma

Desmoplastic Small Round Cell Tumor

September 1, 2024

Desmoplastic Small Round Cell Tumor: Establishment and Validation of New Cell Lines and Therapeutic Targeting of the EWS-WT1 Transcription Factor using Splice Switching Oligonucleotides

Malignant Peripheral Nerve Sheath Tumour

September 1, 2024

The immunomodulatory effects of RAS signaling pathway inhibitors in MPNST

Angiosarcoma

September 1, 2024

A Novel Genetically Engineered Mouse Model for Angiosarcoma: Molecular Characterization and Comparison to Human Angiosarcoma to Develop Targeted Therapy

Osteosarcoma

September 1, 2024

The Role of RECQ Helicases in the Pathogenesis of Osteosarcoma

Mesenchymal Chondrosarcoma

September 1, 2024

The PDGF/PI3K/AKT Axis in Mesenchymal Chondrosarcoma: Functional Characterization and Implications for Anticancer Therapy

Angiosarcoma

September 1, 2024

Identification of Causative Genetic Networks in Angiosarcoma

Desmoplastic Small Round Cell Tumor

September 1, 2024

Identification of novel drug targets and predictors of clinical outcomes in desmoplastic small round cell tumors using next-generation sequencing

Synovial Sarcoma

September 1, 2024

Development of a Mouse Model of Synovial Sarcoma

Synovial Sarcoma

September 1, 2024

Identifying the sources of synovial sarcoma

Ewing Sarcoma

September 1, 2024

Modeling, Characterizing, and Targeting Aggressive, STAG2-mutated Ewing Sarcoma

Ewing Sarcoma

September 1, 2024

Multi-faceted immunostimulatory therapy for Ewing Sarcoma (MITES)

Ewing Sarcoma

September 1, 2024

Epigenetic Mechanisms underlying Ewing Sarcoma Pathogenesis

Ewing Sarcoma

September 1, 2024

Global impact of the DNA/RNA helicase DHX9 on the processing of coding and noncoding transcripts in Ewing sarcoma pathogenesis

Clear Cell Sarcoma of Soft Tissue| Synovial Sarcoma| Undifferentiated Pleomorphic Sarcoma| Angiosarcoma| Alveolar Soft Part Sarcoma

September 1, 2024

Phase I-II trial of sunitinib plus nivolumab after standard treatment in advanced soft tissue and bone sarcomas

Myxoid Liposarcoma

September 1, 2024

Obstruction of Transcription at Tumorigenic Chromosomal Translocations as Therapy

| Osteosarcoma

September 1, 2024

Redirecting B7H3 CAR T cells To Sarcoma using Midkine Receptors

Undifferentiated Pleomorphic Sarcoma

September 1, 2024

Switching the tumor immune microenvironment from “cold” to “hot” in UPS

September 1, 2024

Evaluation of the Hedgehog Signaling Pathway in the Growth of Myogenic Sarcomas

All

September 1, 2024

Sarcoma Cell Line Resource with Molecular and Kinase Annotation

Angiosarcoma

September 1, 2024

ROS1 kinase as a candidate molecular target in angiosarcoma

Angiosarcoma| Malignant Peripheral Nerve Sheath Tumour| Synovial Sarcoma| Undifferentiated Pleomorphic Sarcoma

September 1, 2024

Reversing Exhaustion of Anti-Sarcoma T cells

Osteosarcoma

September 1, 2024

Analysis and Implications of the Difference in Response Rates to a Treatment For Metastatic Osteosarcoma

Leiomyosarcoma

September 1, 2024

Genomic and Spatial Landscapes of Leiomyosarcoma with Germline Pathogenic Variants

Atypical Lipomatous Tumor| Dedifferentiated Liposarcoma

September 1, 2024

Intratumoral heterogeneity in dedifferentiated liposarcoma

Synovial Sarcoma

September 1, 2024

Targeting the Wnt pathway in synovial sarcoma

Central Atypical Cartilaginous Tumor / Chondrosarcoma, Grade 1| Dedifferentiated Chordoma| Central Chondrosarcoma, Grades 2 and 3

September 1, 2024

Deciphering the effects of IDH mutations on chromatin and differentiation in chondrosarcoma

All

September 1, 2024

Proteomic Analysis of Sarcoma: Molecular Differences between Benign and Malignant Tumors of Bone and Soft Tissue

Osteosarcoma

September 1, 2024

Dual targeting of CDK4/6 and PI3K/mTOR in high-risk osteosarcoma

All

September 1, 2024

Cancer stem cells and sarcoma

Osteosarcoma

September 1, 2024

The Cancer Genome as a Novel Target for Malignant Osteosarcoma Immunotherapy

Synovial Sarcoma

September 1, 2024

Beta-catenin activation in synovial sarcomagenesis and progression

Secondary peripheral chondrosarcoma, grades 2 and 3| Secondary Peripheral Atypical Cartilaginous Tumor / Chondrosarcoma, Grade 1

September 1, 2024

Polarity and Ploidy in Peripheral Chondrosarcoma

September 1, 2024

How does a sarcoma circumvent fusion oncoprotein-mediated toxicity?

All

September 1, 2024

Predicting treatment response of soft tissue sarcomas to neoadjuvant therapy by imaging proliferation with a FLT-PET/CT scan: a pilot study

Synovial Sarcoma

September 1, 2024

Pluripotent Stem Cell-derived Genome-edited Sarcoma-targeted T cells for Immunotherapy

Dedifferentiated Liposarcoma

September 1, 2024

The sarcoma tumor microbiome as a therapeutic target

Leiomyosarcoma

September 1, 2024

Identifying DNA damage repair-related vulnerabilities in leiomyosarcoma

Undifferentiated Pleomorphic Sarcoma

September 1, 2024

Understand and target ATRX mutation in undifferentiated sarcoma

Atypical Lipomatous Tumor| Myxoid Liposarcoma| Myxoid Pleomorphic Liposarcoma| Dedifferentiated Liposarcoma| Pleomorphic Liposarcoma

September 1, 2024

A novel precision medicine approach to treat advanced liposarcoma

Dedifferentiated Liposarcoma

September 1, 2024

Desmoplastic small round cell tumor: validation and further development of novel active compounds emerging from high-throughput chemical screens and establishment of xenografts for preclinical studies

Myxoid Liposarcoma

September 1, 2024

Imaging response to CD47 mAb immunotherapy in pediatric patients with osteosarcoma

Pleomorphic Liposarcoma

September 1, 2024

Improve functionality and persistence of Chimeric Antigen Receptor redirected T cells in refractory/relapsed sarcoma patients by Beclin1 modulation

Myxoid Pleomorphic Liposarcoma

September 1, 2024

Regulation of sarcomagenesis by the Piwi proteins and their interacting small RNAs (piRNAs)

Gastrointestinal Stromal Tumor

September 1, 2024

Identification of therapeutic strategies to restore cell cycle control in GIST

Angiosarcoma

September 1, 2024

Predicting the response of secondary angiosarcomas to cemiplimab

Ewing Sarcoma

September 1, 2024

EWS-FLI1 triggered opportunistic de novo enhancer assembly activates potential cellular therapy targets in Ewing Sarcoma

Osteosarcoma

September 1, 2024

Comprehensive analysis of osteosarcoma genomes and transcriptomes using long-read sequencing technologies

Ewing Sarcoma

September 1, 2024

Uncovering polygenic signatures of Ewings Sarcoma drug sensitivity during the evolution of resistance

Synovial Sarcoma

September 1, 2024

Modeling Epithelioid Sarcomagenesis in the Mouse

Synovial Sarcoma

September 1, 2024

Examination of the molecular and therapeutic effects of mTOR and PDGFRA inhibition in Advanced Synovial Sarcoma.

Gastrointestinal Stromal Tumor

September 1, 2024

Chromatin accessibility regulates tyrosine kinase inhibitor resistance in Gastrointestinal Stromal Tumors

Ewing Sarcoma

September 1, 2024

C-MYC Target Gene Network in the Ewing’s Sarcoma Cancer Stem Cell

| Conventional Chordoma| Dedifferentiated Chordoma

September 1, 2024

Preclinical Testing of Compounds Identified in a High Throughput Screen as Potential Chordoma Therapies

September 1, 2024

Targeting the Ras-pathway for the treatment of embryonal rhabdomyosarcoma

All

September 1, 2024

Using Molecular Imaging to Identify Microscopic Residual Sarcoma Cells During Surgery

September 1, 2024

Developing an accurate genetic model for rhabdomyosarcoma therapy testing

Osteosarcoma

September 1, 2024

“Targeting the Inactivation of the MYC Oncogene to Treat Osteogenic Sarcoma”

Osteosarcoma

September 1, 2024

Crosstalk between EGFR and IGF1R mediated by polymorphisms in the EGFR promoter as a mechanism for resistance to IGF1R directed therapy in osteosarcoma

Atypical Lipomatous Tumor| Infantile Fibrosarcoma| Adult Fibrosarcoma| Myxofibrosarcoma| Low-Grade Fibromyxoid Sarcoma| Sclerosing Epithelioid Fibrosarcoma| Dedifferentiated Liposarcoma

September 1, 2024

CAR T Cell Therapy for Sarcoma

Osteosarcoma

September 1, 2024

A small molecule inhibitor of AXL is a novel therapeutic strategy in osteosarcoma

September 1, 2024

Identify and characterize therapeutic targets against cancer stemness and chemotherapy resistance in rhabdomyosarcoma

September 1, 2024

Next Generation CRISPR Phenotypic Screens for Identification of Novel Therapeutic Targets in Rhabdomyosarcoma

September 1, 2024

Targeting YAP/HIPPO pathway in embryonal rhabdomyosarcoma

Undifferentiated Pleomorphic Sarcoma

September 1, 2024

Prognostic and Predictive Immune Signatures in Undifferentiated Pleomorphic Sarcomas

Atypical Lipomatous Tumor| Undifferentiated Pleomorphic Sarcoma| Dedifferentiated Liposarcoma

September 1, 2024

Evaluating the Chromatin Accessibility Landscape as a Driver of Clinical Behavior in Primary Treatment Naive Liposarcoma

Ewing Sarcoma

September 1, 2024

Translational assessment of predictive factors of response of Ewing sarcoma to genotoxic therapy

Ewing Sarcoma

September 1, 2024

Characterization of the function of a novel lncRNA in Ewing’s sarcoma using genomics and proteomics

Angiosarcoma

September 1, 2024

Targeting the sarcoma tumor microenvironment using adrenergic receptor antagonists

Leiomyosarcoma

September 1, 2024

Study of the mechanisms of sarcoma progression using mouse models and in vitro manipulation of mesenchymal stem cells

Malignant Peripheral Nerve Sheath Tumour

September 1, 2024

RalA as a novel target for treatment of MPNST

Osteosarcoma

September 1, 2024

Using 3D bioprinting technologies to Create an Organ-on-Chip Device for Osteosarcoma and Its Surrounding Bone Microenvironment: A Platform for Drug Discovery and Therapeutic Innovation

Synovial Sarcoma| Ewing Sarcoma| Osteosarcoma

September 1, 2024

BiCAR-VZV T cells for the treatment of Sarcoma

September 1, 2024

Role of SFRP3 in PAX3-FOXO1-positive alveolar rhabdomyosarcoma

Malignant Peripheral Nerve Sheath Tumour

September 1, 2024

Mechanisms of tumor progression and kinome targeting in peripheral nerve sheath tumors

All

September 1, 2024

Pharmacodynamic assessment of AKT and SRC inhibitors in primary human sarcoma xenograft models

Desmoplastic Small Round Cell Tumor

September 1, 2024

Identifying EWS::WT1 Control and The Utility of Neogenes in Desmoplastic Small Round Cell Tumors

Desmoplastic Small Round Cell Tumor

September 1, 2024

Omic characterization of DSRCT and establishing the role of fibroblasts

Osteosarcoma

September 1, 2024

Carbon-ion radiotherapy for enhancing treatment response to osteosarcoma

Infantile Fibrosarcoma| Adult Fibrosarcoma| Myxofibrosarcoma| Low-Grade Fibromyxoid Sarcoma| Sclerosing Epithelioid Fibrosarcoma

September 1, 2024

Sarcoma Immunotherapy by Attenuated Salmonella Typhimurium Engineered for Tumor Specific Production of Immunomodulators.

Adult Fibrosarcoma

September 1, 2024

Enhanced NK cell Immunotherapy for Treatment of Chemotherapy Refractory Sarcoma

Myxofibrosarcoma

September 1, 2024

Hypoxia-Associated Multiomic Changes in Myxofibrosarcoma and Undifferentiated Pleomorphic Sarcoma

Low-Grade Fibromyxoid Sarcoma

September 1, 2024

Development of T cell receptors targeting the common cancer antigen PRAME in pediatric malignancies

Sclerosing Epithelioid Fibrosarcoma

September 1, 2024

Characterizing the Genetic Landscape of Radiation Associated Cutaneous Angiosarcomas

Osteosarcoma

September 1, 2024

Identification of molecular targets promoting differentiation and loss of self renewal in osteosarcoma

Undifferentiated Pleomorphic Sarcoma

September 1, 2024

Dissecting Mechanisms of Immune Mediated Radiation Resistance in Sarcomas

Osteosarcoma

September 1, 2024

Identifying chemoresistance pathways in Osteosarcoma.

All

September 1, 2024

Predicting Chemotherapy Response in Sarcoma using Molecular and Imaging Data Collected in a Digital Registry

Ewing Sarcoma

September 1, 2024

Identification of novel therapeutic targets in Ewing’s Sarcoma by modeling tumorigenesis in differentiating human embryonic stem cells.

September 1, 2024

A role for injury in sarcomagenesis

Osteosarcoma

September 1, 2024

An in vivo study of molecular genetics of Rb-dependent osteosarcoma

Ewing Sarcoma

September 1, 2024

Evaluation of ctDNA as a prognostic biomarker in patients with localized Ewing sarcoma

September 1, 2024

Understanding the determinants of cell fate decisions in pediatric rhabdomyosarcomas

Angiosarcoma

September 1, 2024

Targeting Angiosarcoma Vascular and Metabolic Signaling by Blocking Beta Adrenergic Receptor Signaling

Leiomyosarcoma

September 1, 2024

Resetting the epigenetic addiction in leiomyosarcomas: a therapeutic perspective

Osteosarcoma

September 1, 2024

The Role of MYC Amplification in Shaping the Osteosarcoma Tumor Microenvironment

All

September 1, 2024

Boosting Tumor Immunogenicity to Enhance Response to Immune Checkpoint Inhibitors in Soft Tissue Sarcomas

All

September 1, 2024

Discovery of small molecule inhibitors of the MDM2-ubcH5 interaction

All

September 1, 2024

Mechanisms of Arginine Starvation Induced Cell Death

All

September 1, 2024

Determining Doxorubicin Effects on Plasma Extracellular Vesicles Using Proteomics Analysis

All

September 1, 2024

Targeting the alterations of Lipid Metabolism in ASS1 Deficient Sarcomas to Induce Synthetic Lethality

Synovial Sarcoma

September 1, 2024

Targeting the Pentose Phosphate Pathway for the Treatment of Synovial Sarcoma

Synovial Sarcoma| Ewing Sarcoma| Osteosarcoma| Leiomyosarcoma

September 1, 2024

A METABOLOMIC APPROACH TO TARGETING ASS1 DEFICIENT SARCOMAS

September 1, 2024

Plexin-Semaphorin: a new signaling axis in Sarcomas

All

September 1, 2024

Therapeutically targeting aberrant chromatin remodeling in sarcomas

Osteosarcoma

September 1, 2024

Interrogating the regulation, function and therapeutic potential of monocarboxylate transporters in osteosarcoma

September 1, 2024

Unwinding new therapeutic opportunities in rhabdomyosarcoma: the role of RNA helicase DDX5

All

September 1, 2024

Delineating Strategies to Enhance Immunotherapy Response via Microbial Targeting of Tertiary Lymphoid Structures

Inflammatory Myofibroblastic Tumour

September 1, 2024

Identifying and characterizing actionable kinase fusions in Inflammatory Myofibroblastic Tumors

Osteosarcoma

September 1, 2024

Improving T-cell Therapy for Osteosarcoma

Osteosarcoma

September 1, 2024

B7-H3-Engager T cells for the immunotherapy of osteosarcoma

Leiomyosarcoma

September 1, 2024

Omic patterns of sensitivity and resistance to existing agents- exanded

Ewing Sarcoma

September 1, 2024

Development of Novel RNA Sensor-Based Treatment for Ewing’s Sarcoma

Spindle Cell / Sclerosing Rhabdomyosarcoma| Osteosarcoma

September 1, 2024

Uncover principles underlying cryoablation-induced immunotherapy effects in sarcomas

Extrarenal Rhabdoid Tumor

September 1, 2024

Epigenetic control of stem cell identity in rhabdoid sarcomas

Dedifferentiated Liposarcoma

September 1, 2024

Evaluation of the oncogenic potential of genes within the 1q23 amplicon

Undifferentiated Pleomorphic Sarcoma

September 1, 2024

Improving CAR-T cell immunotherapy in immunocompetent sarcoma models

Synovial Sarcoma| Undifferentiated Pleomorphic Sarcoma

September 1, 2024

A Quantitative Imaging-based Biomarker for Assessment of Therapy Response in Soft Tissue Sarcomas by Differential Volume Estimation of Viable and Non-viable Tumor Fractions

Desmoid Fibromatosis| Ewing Sarcoma| Osteosarcoma|

September 1, 2024

Rational biomarker-guided PARP inhibitor combination therapy in pediatric sarcomas

PEComa (Perivascular Epithelioid Tumour)

September 1, 2024

Integrative multi-Omic analysis of PEComa: biomarkers and novel therapeutic targets

September 1, 2024

Immune profiling of pleomorphic rhabdomyosarcoma

Atypical Lipomatous Tumor| Dedifferentiated Liposarcoma

September 1, 2024

Proteomic and genomic approaches to understanding intrinsic and acquired resistance to CDK4 inhibition therapy in well differentiated/dedifferentiated liposarcoma

Dedifferentiated Liposarcoma

September 1, 2024

Dissecting DNA damage and repair pathways in leiomyosarcomas: Improving therapy by understanding biology

Central Atypical Cartilaginous Tumor / Chondrosarcoma, Grade 1| Dedifferentiated Chordoma| Central Chondrosarcoma, Grades 2 and 3

September 1, 2024

Targeting the retinoid acid pathway: a new therapeutic strategy for IDH1/2-mutant chondrosarcomas

Kaposi Sarcoma

September 1, 2024

Towards an improved Kaposi sarcoma immunotherapy: Investigating the interplay of the oncogenic Kaposi sarcoma herpesvirus G-protein coupled receptor with the host chemokine system

Leiomyosarcoma

September 1, 2024

Hippo pathway targeting in uterine leiomyosarcoma

Synovial Sarcoma

September 1, 2024

MCL-1 inhibition unmasks BCL-2 addiction in synovial sarcoma

Ewing Sarcoma

September 1, 2024

Targeting EWS-FLI1 Ewing Sarcoma through a rationale targeted therapy combination

Undifferentiated Pleomorphic Sarcoma

September 1, 2024

Evaluating myeloid cells as targets to promote anti-tumor immunity in undifferentiated pleomorphic sarcoma

Ewing Sarcoma

September 1, 2024

Development of a high throughput screening assay for Ewing sarcoma oncoprotein

Leiomyosarcoma| SFA

July 11, 2024

Maximizing responses to DNA damage-inducing therapies in Leiomyosarcoma (LMS)