Proteomic characterization identifies clinically relevant subgroups of soft tissue sarcoma
A study entitled, “Proteomic characterization identifies clinically relevant subgroups of soft tissue sarcoma” is another study that looks at the functional classification of soft tissue sarcoma; this time by the proteins expressed in the tumors of 272 patients from 12 different subtypes in China. In their analysis, they find a similarity between angiosarcoma (AS) and epithelial sarcoma (ES), and elevated expression of one protein in particular (SHC1) is correlated with poor prognosis in these subtypes. Additionally, they find that when they group the subtypes by the proteins expressed that there are three different groups each driven by different cell pathways and with different patient outcomes. Their analysis also identified the three immune subtypes with different tumor microenvironments. Additional research needs to be done, but this study continues the insights that have developed by characterization of multiple subtypes of sarcoma using a variety of testing methods.