Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization
This research was partly funded by grants from SFA. In the study, “Osteosarcoma tumors maintain intra-tumoral transcriptional heterogeneity during bone and lung colonization,” investigators demonstrated that osteosarcoma tumors continue to express a high level of different genes from cell to cell within a tumor, even when different genes are expressed as tumors metastasize to the tibia and lungs. Additionally, different tumors continue to have subpopulations of cells that express similar certain gene pathways within each environment. How these differences are regulated in osteosarcoma cells and whether differences in genomic expression bring about these differences remain unanswered but are important questions to be researched.