Multimodal Profiling of Chordoma Immunity Reveals Distinct Immune Contextures
Recent research indicates that chordomas can respond to immunotherapies. In the paper, “Multimodal Profiling of Chordoma Immunity Reveals Distinct Immune Contextures,” the researchers use a variety of methods to better understand this potential for immunotherapies as a treatment for chordoma tumors. The researchers analyzed tumor samples from 77 patients and identified two distinct groups based on the presence of a subset of white blood cells called T cells. The group with greater numbers of T cells also had higher numbers of other white blood cells. Tumors with fewer T cells also had fewer immune cells. These results provide additional evidence for chordoma tumor cells asm reasonable candidates for T cell-mediated immunotherapy. While additional research is still required, this study provides further evidence for the use of immunotherapy in chordoma.