Genomic, transcriptomic, and immunogenomic landscape of over 1300 sarcomas of diverse histology subtypes
The investigators performed whole exome sequencing and RNA sequencing on over 1,300 total specimens from over 1,200 patients representing 42 sarcoma subtypes. After analyzing this data, they found that there were mutations that occurred repeatedly and there was an increase in mutations in metastatic specimens compared to primary tumors. Additionally, they were able to develop estimates of immune cells in the tumors which clustered into 5 groups from low numbers to high numbers of immune cells with overall survival being lower in tumors with fewer immune cells compared to those with increased immune cells. This study encompasses a large number of specimens in a significant number of sarcoma subtypes and demonstrates that there is important information to be derived from the sequencing of tumor samples across the sarcoma landscape.
Read the full study in Nature Communications.