STUDY OF LOXO-101 IN SUBJECTS WITH NTRK FUSION POSITIVE SOLID TUMORS
This phase 2 study will enroll patients of all tumor types, including sarcomas, who have a specific abnormality in the tumor called a fusion of one of the cancer cell’s NTRK genes (NTRK -1, -2, or -3) which may cause the sarcoma to grow. The study drug, LOXO-101, is a capsule and acts by blocking the effects of the NTRK fusions in these cancers. This study will measure how well and for how long LOXO-101 works. Patients with a sarcoma who would not be able to receive any other options for treatment can participate in this trial. If you are not sure if your cancer has one of these NTRK fusions, talk to your doctor about available options to have your tumor tissue tested.
ClinicalTrials.gov: https://clinicaltrials.gov/ct2/show/NCT02576431?term=NCT02576431&draw=2&rank=1