The landscape of alterations from 1407 ultra-rare sarcomas from the AACR GENIE database: Clinical implications
Highlighting a study in ultra-rare sarcomas (sarcomas that occur in fewer than 1/1,000,000 people per year).
In the study “The landscape of alterations from 1407 ultra-rare sarcomas from the AACR GENIE database: Clinical implications,” researchers analyzed the genomic sequencing of 1,407 soft tissue and bone ultra-rare sarcomas from the American Association for Cancer Research (AACR) GENIE database. They found approximately a quarter of ultra-rare sarcomas have potentially clinically actionable mutations. These findings suggest that genomic sequencing of ultra-rare sarcomas has the potential to open additional treatment options for these patients. However, additional studies are needed to determine whether these genetic alterations are as predictive of responses in ultra-rare sarcomas as they are in other cancers.